![proteus syndrome skeleton proteus syndrome skeleton](https://d3i71xaburhd42.cloudfront.net/9b7fe9f1c3c82b5459eb84282427e0f892f3c696/2-Figure3-1.png)
Although skeletal features predominate, the disease may affect any tissue and lead to the overgrowth of brain, skin, adipose, vasculature, immune, gut, and other tissues (Fig. We conclude that the predisposition to thrombosis is likely to be multifaceted with risk factors including vascular malformations, immobility, surgery, additional prot. Proteus syndrome (PS) causes asymmetric, disproportionate, and severe postnatal overgrowth, particularly bone, in a mosaic pattern. We observed that eight of 17 patients had an abnormal D-dimer level >0.5 mcg/dl, but deep venous thromboses occurred in only four of those with D-dimer >1.0 mcg/dl.
![proteus syndrome skeleton proteus syndrome skeleton](https://ichef.bbci.co.uk/news/660/cpsprodpb/100FF/production/_89919756_elephant_man_index.jpg)
Not only all of them shared identical systemic involvement, but also caused several very specific anomalies in various parts of the body.
![proteus syndrome skeleton proteus syndrome skeleton](https://images.slideplayer.com/23/6870747/slides/slide_82.jpg)
Eleven of 21 patients had an abnormal hypercoagulable panel including Factor V Leiden heterozygotes, antithrombin III deficiency, positive lupus anticoagulant, or Protein C or S deficiencies. It has been found that Marfan syndrome, Proteus syndrome, and Progeria commonly affected musculo-skeletal system, cardiovascular system, eye, and nervous system. Of the remaining 47 living patients, six had thromboembolic events that all occurred postoperatively and in an affected limb. We found that six of ten patients, who were deceased, died secondary to deep venous thrombosis and/or pulmonary embolism. various structures of the body: skin, skeleton, skull, upper and lower limbs. We conducted a comprehensive review of the medical histories and hematologic evaluations of 57 patients with Proteus syndrome to identify potential risk factors for thrombosis. A case of Proteus syndrome with otolaryngologic interest is presented. Proteus syndrome is a mosaic, progressive overgrowth disorder involving vasculature, skin, and skeleton, and caused by a somatic activating mutation in AKT1. Patients with overgrowth and complex vascular malformation syndromes, including Proteus syndrome have an increased risk of thromboembolism. Bethesda, Md., Wed., JA team of researchers has identified the genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grows massively out of proportion.The discovery, which has implications for potential drug therapies and even cancer, appears in the July 27, 2011, early online edition of The New England Journal of Medicine.